Research in Dundee (Archive)

We support research across all the fields of clinical, biomedical, physical or engineering sciences related to medicine. The following are awards made to researchers working in Dundee's universities and hospitals between 1992 and 2001. [Link to information about more recent awards]

Awards in 2000-01

£70,000 over two years to Dr Cameron J. Weir & Professor J.A.W. Wildsmith (Anaesthesia) and Profesor Jeremy J. Lambert (Pharmacology & Neuroscience, Dundee University) for characterisation of general anaesthetic binding site(s) on human GABAA receptors.
In spite of their regular use, the mechanisms behind the effects of general anaesthesia are largely unknown. This research will study the components of GABAA receptors which interact specifically with general anaesthetics.
£99,573 over two years to Drs Michelle J. Ferguson (Cancer Medicine), Theodore R. Hupp, Neil M. Kernohan (Molecular & Cellular Pathology) and Professors Robert J.C. Steele (Surgical & Molecular Oncology) and Elaine M. Rankin (Cancer Medicine, Ninewells Hospital & Medical School, Dundee) to develop novel strategies for the treatment of colorectal cancer.
The p53 gene pathway is necessary for cells to undergo programmed cell death, known as apoptosis. However, p53 is mutated in many colorectal cancer patients, making treatment challenging. This research considers ways to manipulate the p53 response to improve cell killing when accompanied by chemotherapy.
£99,418 over three years to Drs Andrew J. Irving and Bruno Frenguelli (Pharmacology & Neuroscience, Dundee University) for a study linking hypoxia/ischaemia with altered glutamate receptor expression and dynamic changes in the neuronal cytoskeleton.
Neurodegeneration following reduced blood flow and oxygen deprivation involves the production of certain receptor complexes which are activated by glutamate, intensifying the damage. By studying these neurotoxic receptors this research hopes to find a way to modify the neurone damage and prevent loss of normal functioning.

Awards in 1999-2000

£19,400 to Professor Jill F. Belch (Vascular Medicine & Biology) Mrs Rosemary Levison (Vascular Laboratory) Profesosr Annie Anderson (Centre for Applied Nutrition Research), Dr J. Stewart Forsyth (Child Health) and Dr Faisel Khan (Vascular Medicine & Biology, Dundee University and Ninewells Hospital & Medical School) for the purchase of equipment for research into aortic compliance, measured by ultrasound echo tracking, as an early marker for vascular disease.
£69,990 over two years to Dr Andrew M. Wilson & Professor Brian J. Lipworth (Clinical Pharmacology & Therapeutics, Dundee University) to study the clinical and histological outcomes in allergic airways disease and the efficacy of combined mediator antagonism or topical corticosteroid treatment.
The Cruden Medical Research Scholarship 2000-01 was awarded to Ms Amy Leslie (Surgery, Ninewells Hospital & Medical School, Dundee) to study the genetic mutations asociated with both colorectal cancer and the polyps which precede it, to clarify whether they might prove useful as markers in early screening for the disease.

Awards in 1998-99

£70,000 over two years to Dr Keiran C. Breen (Pharmacology, Dundee University) to continue his research into the role of tau protein glycosylation in the generation of neurofibrillary tangles associated with Alzheimer's Disease.
£87,119 over two years to Drs Christopher N. Connolly & John Peters and Professor Jeremy Lambert (Neurosciences Institue, Ninewells Hospital & Medical School, Dundee) for the cloning and characterisation of notel 5-HT3 receptors and interacting proteins that regulate native receptor function.
£40,545 over one year to Miss Dorin Ziyaie, Mr Alastair M. Thompson & Professor Robert J.C. Steele (Surgery) and Dr Theodore R. Hupp (Molecular & Cellular Pathology, Ninewells Hospital & Medical School, Dundee) and Dr Kathryn L. Ball (Biochemistry, Dundee University) to study regulation of p53 activity during breast cancer treatment.

Awards in 1997-98

£1,235 for a 5-month pilot study to Dr Lawrence Elliott (School of Nursing & Midwifery, Dundee University) Dr Avril Taylor (Behavioural Studies, Scottish Centre for Infection & Environmental Health, Ruchill Hospital, Glasgow) and Mr Simon Ogston (Epidemiology & Public Health, Dundee University) to study the long-term impact of needle exchanges on injecting-related risk behaviour.
£30,415 over one year to Dr Malcolm P. Caulfield (Pharmacology & Neuroscience, Ninewells Hospital & Medical School, Dundee) for a study of metatropic glutamate receptors in cerebellar Purkinje neurones.
£13,807 to Dr Meilien Ho, Professor Jill F. Belch & Dr Margaret McLaren (Medicine, Dundee University) and Professor George Nuki (Medicine, Western General Hosptial, Edinburgh) for a pilot study lasting three months to investigate oxidised low density lipoprotein and homocysteinaemia sclerosis.
£66,558 over 18 months to Drs Faisel Khan, Margaret McLaren, Stephen A. Greene & Alexander Hill and Professor Jill F. Belch (Medicine, Dundee University) to study the effects of oral antioxidants and L-arginine on macrovascular function in young people with Type I diabetes mellitus.

Awards in 1996-97

£85,285 to Mr Robert P. Mills (Otolaryngology, Ninewells Hospital & Medical School, Dundee) and Dr Eric W. Abel (Biomedical Engineering, Dundee University) for a two-year in vitro evalulation of physiological models of the ossicular chain.
£94,237 to Dr Ian J. Holt (Molecular & Cellular Pathology, Ninewells Hospital & Medical School, Dundee) & Dr Alan R. Prescott (Biochemistry, Medical Science Institute, Dundee University) for a three-year project analysing innervated cultured muscle from patients with mitochondrial disease.
£30,391 to Dr Kieran Breen (Pharmacology, Ninewells Hospital & Medical School, Dundee) for a one-year study of the role of Tau protein glycosylation in the generation of neurofibrillary tangles associated with Alzheimer's Disease.
£99,697 to Dr Bruno Frenguelli (Pharmacology, Ninewells Hospital & Medical School, Dundee) for a three-year investigation into neuronal function after hypoxia/ischaemia in the in vitro rat hippocampal slice.

Awards in 1995-96

£63,539 to Dr Malcolm P. Caulfield (Pharmacology & Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee) for a study to define the transduction pathways inducing long-term synaptic depression and release of calcium from intracellular stores by investigating the metabotropic glutamate receptors in cerebellar Purkinje neurones.
£12,363 as a supplement to Drs Michael W.H. Coughtrie (Biochemical Medicine) and John A. Mills (Reproductive Medicine Unit, Ninewells Hospital & Medical School, Dundee) for their investigation of the regulation by sulphation of steroid hormone activity in the human female reproductive tract and its relationship to infertility and early pregnancy loss.

Awards in 1993-94

£15,320 for one year to Drs Jill J.F. Belch & F. Khan (Medicine, Dundee University) and Dr Margaret McLaren and Sister Roberta Littleford (Vascular Medicine, Ninewells Hospital & Medical School, Dundee) for a study of fibrinolysis and endothelial cell function in patients with Raynaud's Phenomenon.
£89,854 over three years to Dr Kieran C. Breen (Pharmacology & Clinical Pharmacology, Dundee University) for a study of neural glycosylation state in Alzheimer's Disease.

Awards in 1992-93

£88,668 to Dr Michael W.H.Coughtrie (Biochemical Medicine), Drs David H. Edgar & John A. Mills (Obstetrics & Gynaecology, Ninewells Hospital & Medical School, Dundee) for a three-year investigation of the regulation of steroid hormone activity in the human female reproductive tract and its relationship to infertility and early pregnancy loss.
The Cruden Medical Research Scholarship 1993-94 was awarded to Dr Robert I. Cargill (Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee) to study the effects of vasoactive peptides on the pulmonary vascular bed.

[Link to information about more recent awards]